Apigenin's most pharmacologically significant activity in aging is CD38 inhibition — with an IC50 of approximately 0.7 μM, far more potent than quercetin (20 μM) for CD38 inhibition. This makes apigenin a uniquely effective NAD+ preservation supplement at low doses. At higher doses, apigenin also inhibits BCL-2 family proteins with senolytic potential.

Can chamomile tea provide therapeutic apigenin doses?

Chamomile tea provides 3–10 mg apigenin per cup. For CD38 inhibition at the 0.7 μM IC50, plasma apigenin levels from tea consumption may approach meaningful CD38-inhibitory concentrations. 3–4 cups/day of strong chamomile tea is a reasonable dietary strategy.

Should I take apigenin if I'm already taking quercetin?

Apigenin and quercetin have complementary activity — apigenin is better for CD38 inhibition; quercetin is better for senolytic activity. Combining them provides broader coverage without redundancy.