The simplest evidence-backed senolytic protocol: (1) Fisetin 20 mg/kg × 2 days per month for senolysis, (2) Quercetin phytosome 200 mg/day continuous for anti-inflammatory maintenance. This covers senescent cell clearance and ongoing SASP suppression with two natural, well-tolerated compounds requiring no prescription.

How long until I feel something from senolytics?

Some users notice improved energy and recovery within 1–3 cycles. Measurable biomarker changes typically require 3–6 months. Structural cellular improvements (reduced senescent cell burden) occur without necessarily being felt directly.

Should I tell my doctor I'm taking senolytics?

Yes. Inform your primary care physician of all supplements. Fisetin and quercetin are natural compounds with excellent safety records, but your physician should be aware for complete medical history.