NAD+ IV therapy requires a qualified medical provider. Look for providers with anesthesia or addiction-medicine background, established protocols, and post-session monitoring.

Selection criteria. Medical doctor or NP supervision; established NAD+ protocols (250–1500 mg titrated); pre-session intake and post-session follow-up; transparent pricing.

This guide ranks our top picks, explains the methodology, and gives you a clear protocol for getting started.

NAD+ (nicotinamide adenine dinucleotide) is a redox coenzyme present in every cell. It powers mitochondrial ATP production via the electron-transport chain, fuels DNA-repair enzymes (PARPs), and is the obligatory substrate for sirtuins (SIRT1–SIRT7) — the enzyme family that controls gene expression, inflammation, and cellular survival.

NAD+ levels fall by 50% or more between ages 30 and 60. That decline is now considered a leading mechanistic explanation for age-related metabolic dysfunction, mitochondrial fatigue, accumulation of senescent cells, and the loss of muscle, skin, and cognitive resilience seen in aging.