The D+Q protocol stands as the single most evidence-backed senolytic intervention in human medicine. The Xu et al. (2018) Nature Medicine paper demonstrated: measurable reduction in p16+p21-positive senescent cells in adipose tissue biopsies, reduction in circulating SASP factors (IL-6, MMP-3, MMP-9), and improvement in physical function (walking speed, chair stand, stair climbing) in patients with idiopathic pulmonary fibrosis.

How do I access dasatinib for longevity purposes?

Dasatinib is a prescription medication (Sprycel®, Bristol-Myers Squibb). In most countries, prescription requires physician evaluation. Longevity medicine practitioners, internists, and some gerontologists may prescribe it off-label for aging indications. Aging.ai and similar directories list longevity physicians.

What monitoring is required with D+Q?

CBC (platelet count monitoring for thrombocytopenia risk), liver function tests, and cardiac evaluation (ECG for QTc prolongation) are standard pre-treatment assessments. Repeat CBC after the first cycle is recommended.