EGCG at concentrations achievable with 3–5 cups of green tea (or 400–800 mg supplement) inhibits SASP production via NF-κB suppression, activates autophagy via AMPK and PI3K/mTOR inhibition, and at higher concentrations exerts selective cytotoxicity in senescent cells via ROS-mediated mechanisms. Its combination of mechanisms makes it a mild but multifaceted anti-aging catechin.

Green tea provides EGCG at concentrations with demonstrated SASP suppression and mild senolytic activity. Regular green tea consumption (3–5 cups/day) is a senolytic-adjacent lifestyle choice. Supplemental EGCG provides higher concentrations for more pronounced effects.

What dose of EGCG is safe long-term?

Doses up to 800 mg/day EGCG have been used in clinical studies without significant adverse effects. The liver toxicity risk from EGCG occurs primarily at doses >1,200 mg/day, particularly fasted. Take with food and stay within 400–800 mg/day for safe chronic use.