Fisetin crosses the blood-brain barrier and reduces neuroinflammation, tau hyperphosphorylation, and amyloid-beta plaque formation in multiple Alzheimer's disease animal models. The Alzheimer's Research Association-funded MEND-AD trial is currently evaluating fisetin in human subjects with mild cognitive impairment.

Can fisetin prevent Alzheimer's disease?

Current evidence is preclinical. Fisetin cannot be claimed to prevent or treat Alzheimer's. However, its multi-target mechanisms (senolytic, anti-tau, anti-amyloid, anti-inflammatory) make it a promising preventive candidate in high-risk populations.

What dose is used for brain health?

For neuroprotection, lower continuous doses (100–200 mg/day) are used by some practitioners in addition to periodic burst dosing (20 mg/kg, 2 days). Human trial data for specific neuroprotective doses is still emerging.