Fisetin (3,3′,4′,7-tetrahydroxyflavone) is a naturally occurring flavonoid found primarily in strawberries. The landmark 2018 Scripps Research study demonstrated that fisetin reduced senescent cell burden by 25–50% in late-life mice and extended median remaining lifespan by 10%. Human extrapolation suggests a dose of 20 mg/kg body weight for senolytic effects.

What is the optimal fisetin dose for senolysis?

The evidence-based dose extrapolated from the Yousefzadeh (2018) mouse study is 20 mg/kg body weight. For a 70 kg adult, this equals approximately 1,400 mg/day. This is taken for 2 consecutive days, then stopped for at least 3–4 weeks.

Daily low-dose fisetin (100–200 mg) is used by some practitioners for its non-senolytic benefits (anti-inflammatory, neuroprotective). For senolytic purposes specifically, burst dosing (2 days on, extended time off) better mimics the evidence base.

Does fisetin cross the blood-brain barrier?