No head-to-head human trial has directly compared monthly vs quarterly fisetin senolytic cycling. Based on senescent cell reaccumulation kinetics from animal studies (approximately 30% recovery within 4 weeks of clearance in aged mice), monthly cycling may be superior for maintaining a low senescent cell burden, while quarterly dosing may be sufficient for prevention in younger individuals.

How do I know if I need monthly vs quarterly cycling?

Higher-frequency cycling is favored if you have chronic inflammation markers (elevated CRP, IL-6), are over 55, have metabolic syndrome, or have experienced significant cellular stress (illness, radiation, chemotherapy).

Can I track senolytic effectiveness at home?

High-sensitivity CRP, ferritin, and IL-6 (via extended labs) can serve as indirect proxies for SASP-driven inflammation. Improvements in these markers after cycling sessions suggest effective senolytic activity.