Testosterone exerts anti-senescence effects in male physiology, and its gradual decline after age 30–35 (approximately 1%/year) accelerates senescent cell accumulation in skeletal muscle (satellite cells), adipose tissue, and testicular Leydig cells. Fisetin senolytic protocols may complement testosterone optimization strategies in men over 40.

Does fisetin affect testosterone levels?

No direct effect on testosterone levels has been demonstrated at supplemental doses. Indirectly, by reducing SASP-driven inflammation (which suppresses testosterone via IL-6 and TNF-α inhibition of Leydig cells), fisetin may support a more favorable hormonal environment.

Can fisetin be combined with testosterone replacement therapy (TRT)?

No known contraindication exists. Some practitioners view fisetin as a complementary approach — TRT addresses the hormonal signal; fisetin addresses the cellular senescence driving downstream pathology. Inform your physician.