Orally administered lactoferrin is substantially digested in the stomach (pepsin) and duodenum (trypsin, chymotrypsin), with estimates of 20–60% intact protein surviving gastric transit depending on formulation and fed state. The digestion products (lactoferricin, lactoferrampin) retain significant antimicrobial activity. Enteric-coated lactoferrin delivers more intact protein to the duodenum and small intestine.

Is enteric-coated lactoferrin significantly better than standard?

For applications requiring intact protein (full iron-binding capacity, LfR1-mediated immune cell activation), enteric-coated is superior. For applications where bioactive peptides are sufficient (antimicrobial via lactoferricin, some immune effects), standard capsules remain effective.

Can I open lactoferrin capsules and dissolve in water?

Not recommended. This exposes the powder to gastric acid more rapidly and extensively. If you prefer liquid administration, colostrum powder or lactoferrin specifically formulated for dissolution is a better option.