Abnormal iron accumulation in the brain is a consistent finding in Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions. Free iron catalyzes hydroxyl radical generation that damages neurons, promotes protein aggregation (amyloid-beta, alpha-synuclein), and drives neuroinflammation. Lactoferrin's iron-chelating and anti-inflammatory properties are mechanistically relevant, though brain access from oral supplementation is limited.

Can lactoferrin prevent Alzheimer's disease?

No proven preventive effect. Mechanistic rationale (iron dysregulation, neuroinflammation) is relevant, but no human Alzheimer's prevention trial with lactoferrin has been conducted.

Should people with APOE4 (Alzheimer's risk gene) take lactoferrin?

APOE4 carriers have elevated brain iron accumulation risk. Lactoferrin's iron regulation mechanism is particularly relevant for this genotype. This is a reasonable preventive consideration, ideally discussed with a neurologist.