Cancer cells have 6–10x higher iron demand than normal cells due to rapid proliferation. Lactoferrin restricts tumor iron availability, reduces cancer cell proliferation rates, induces apoptosis directly, and enhances NK cell surveillance that eliminates early cancer cells before clinical disease develops. Human evidence for cancer prevention is limited but mechanistically well-supported.

Can people undergoing cancer treatment take lactoferrin?

Cancer patients should discuss lactoferrin with their oncologist. NK cell activation may be beneficial during immunotherapy. Lactoferrin's iron chelation should not interfere with most standard chemotherapy (which targets DNA and cell division, not iron metabolism). Always disclose supplements during cancer treatment.

How much lactoferrin is needed for cancer prevention benefits?

The Kozu adenoma trial used 1.5 g/day — much higher than typical supplement doses (200–300 mg/day). Standard supplement doses provide the NK cell and iron restriction benefits at more modest magnitude. Higher doses (500–1,000 mg/day) may be more appropriate for those at elevated cancer risk.