Iron catalyzes LDL oxidation via Fenton reaction (Fe²⁺ + H₂O₂ → OH•, which oxidizes LDL polyunsaturated fatty acids to ox-LDL). Ox-LDL is taken up by macrophages in arterial walls, forming foam cells — the initial step of atherosclerotic plaque. Lactoferrin chelates iron, reducing the Fenton reaction rate and consequently reducing LDL oxidation in iron-replete individuals.

Should I check ferritin before taking lactoferrin for cardiovascular purposes?

Checking ferritin is recommended. If ferritin is elevated (>150 ng/mL men, >100 ng/mL women), lactoferrin's iron chelation benefit is most relevant. If ferritin is normal, the anti-inflammatory cardiovascular benefits still apply.

Does lactoferrin affect lipid panel results?

Modest reductions in total cholesterol and LDL-C have been observed in some studies. Serum triglycerides reduce in metabolic syndrome patients. These are secondary effects of reduced adipose inflammation and improved insulin sensitivity rather than direct lipid metabolism effects.