Lactoferrin is present in human breast milk at concentrations of 1-7 mg/mL during early lactation — concentrations orders of magnitude higher than any typical adult supplement dose. Its presence in such abundance during the critical early immune development window underscores its biological importance for pediatric immune function. Clinical trials of bovine lactoferrin supplementation in formula-fed infants and children have consistently demonstrated reductions in respiratory and gastrointestinal infections.