The colon — final destination of lactoferrin and its peptic digestion products (lactoferricin) — is where much of lactoferrin's gut health benefit is expressed: butyrate production from enriched Bifidobacterium, direct anti-proliferative effects on colorectal cancer cells, and reduction in inflammatory mucosal markers via NF-κB inhibition in colonocytes.

Can lactoferrin prevent colorectal cancer recurrence?

The Japanese adenoma recurrence trial is the most relevant human evidence — showing reduced colorectal polyp recurrence with high-dose lactoferrin (1.5 g/day). Lower doses (200–300 mg/day) likely provide attenuated but meaningful colonic protective effects. Not a cancer treatment.

Should I take lactoferrin if I have a family history of colon cancer?

Given the evidence for butyrate promotion, anti-proliferative effects, and adenoma recurrence reduction, lactoferrin is a reasonable supplement for individuals with elevated colorectal cancer risk. Colonoscopy screening remains essential.