Gastric pepsin at pH 1.5–2 degrades lactoferrin significantly. In vitro studies suggest 30–60% of lactoferrin is digested in simulated gastric fluid over 2 hours. Enteric coating delays dissolution until the supplement reaches the duodenum (pH 5.5+), protecting intact lactoferrin for receptor-mediated uptake at LfR1.

How do I know if my enteric-coated lactoferrin is genuine?

Genuine enteric-coated products don't dissolve in the mouth or stomach — only in the intestine. If you notice the capsule dissolving quickly in your mouth, it is likely not properly enteric-coated. Request dissolution test data from the manufacturer.

Is delayed-release the same as enteric coating?

Delayed-release can use enteric coating or other slow-dissolution technologies. True enteric coating specifically targets release at pH 5.5+ (duodenum). Some "delayed release" products may release in the stomach more slowly but not bypass it entirely.