Renal tubular cells are among the highest iron-handling cells in the body — filtering 25–30 mg iron per day from the glomerular filtrate. Excess free iron in the tubular lumen generates ROS via Fenton reaction, damaging tubular cells and driving AKI and CKD progression. Lactoferrin chelates this tubular iron, reducing Fenton-reaction-mediated renal oxidative damage.

Is lactoferrin safe in CKD patients?

Lactoferrin is a naturally occurring milk protein with excellent safety record. No nephrotoxicity has been documented. CKD patients with protein-restricted diets should note lactoferrin contributes minimal protein (~1 g/day at 300 mg supplement). Consult your nephrologist.

Does lactoferrin affect kidney function tests (creatinine, eGFR)?

No direct pharmacological effect on creatinine production or GFR is expected. Over time, reduced tubular inflammation may contribute to stabilized eGFR decline, but short-term test results should not change significantly.