Aging is associated with iron accumulation in vulnerable tissues (brain, liver, heart) despite adequate dietary iron, and with progressive decline in immune function (immunosenescence). Lactoferrin addresses both: its iron sequestration reduces tissue iron-driven oxidative damage, while its immunomodulatory effects restore NK cell function and reduce chronic SASP-like inflammation.

Should everyone over 50 take lactoferrin?

Adults over 50 with elevated ferritin (>150 ng/mL men, >100 ng/mL women), elevated hsCRP, reduced NK activity, or frequent infections are particularly good candidates. Lactoferrin's safety profile makes it appropriate for broad preventive use in aging adults.

Does lactoferrin reduce biological age?

No human biological age clock data exists specifically for lactoferrin. However, its reduction of inflammatory markers (which are components of aging clocks like GrimAge) and iron dysregulation (which accelerates epigenetic aging) suggests potential biological age benefits.