Traditional prebiotics (inulin, FOS, GOS) selectively promote beneficial bacteria by providing fermentable carbohydrate substrates. Lactoferrin promotes the same beneficial bacterial populations (Bifidobacterium, Lactobacillus) by a completely different mechanism — removing iron that competing bacteria require. This iron-restriction prebiotic mechanism is additive with traditional prebiotics.

Should I take lactoferrin instead of probiotic fiber supplements?

They're complementary, not competing. Lactoferrin restricts iron (creates a favorable environment). Prebiotic fiber provides substrate (Bifidobacterium food). Probiotics deliver live bacteria directly. A complete gut health protocol uses all three.