Lactoferrin is a naturally occurring human milk protein with an outstanding safety record. Clinical trials using doses of 100–600 mg/day for 3–6 months report no serious adverse events in any study. The most relevant safety considerations are: milk protein allergy (contraindication), and caution in hereditary hemochromatosis where iron dynamics may be affected.

Can people with a history of dairy-related digestive issues take lactoferrin?

Depends on the cause. Lactose intolerance: safe (no lactose in lactoferrin supplements). Dairy protein sensitivity: not the same as true allergy; consult a physician. Diagnosed milk protein allergy (IgE-mediated): avoid.

Is lactoferrin safe during pregnancy?

Multiple clinical trials in pregnant women have used lactoferrin for iron deficiency supplementation with no adverse pregnancy outcomes. Lactoferrin is considered safe in pregnancy and may be superior to iron salts for treating pregnancy-related iron deficiency.