A meta-analysis of 8 RCTs found lactoferrin supplementation reduces URTI incidence by ~33% (pooled RR 0.67) during cold and flu season. The dual mechanism — direct antiviral HSPG blocking and NK cell immune enhancement — provides both immediate antiviral protection and sustained immune competence throughout the high-exposure season.

When should I start my seasonal lactoferrin protocol?

Start 2–4 weeks before your typical cold and flu season begins (often early to mid-October in northern regions). Starting before exposure allows immune priming effects to establish.

Should I continue lactoferrin if I'm already sick with a cold?

Yes — increase the dose. During active infection, higher lactoferrin doses (400–600 mg/day) may help reduce symptom duration and severity by providing antiviral pressure throughout the infection course.