SIBO (Small Intestinal Bacterial Overgrowth) involves >10⁵ bacteria/mL in small intestinal aspirates, causing bloating, malabsorption, and nutritional deficiencies. Lactoferrin delivered to the small intestine (via enteric-coated formulations) provides iron restriction and lactoferricin bactericidal activity directly in the affected region — potentially complementing standard SIBO treatment (rifaximin, elemental diet).

Is lactoferrin a replacement for rifaximin in SIBO?

No. Rifaximin is the evidence-based first-line SIBO treatment. Lactoferrin is a complementary agent that may improve treatment outcomes and reduce recurrence rates. Do not substitute lactoferrin for rifaximin without gastroenterologist guidance.

Can a breath test confirm lactoferrin's effect on SIBO?

Hydrogen and methane breath tests measure bacterial fermentation gases. If lactoferrin reduces SIBO bacterial load, breath test results may improve over time. Testing before and after 4–8 weeks of lactoferrin supplementation could provide objective evidence of effect.