Resveratrol excited the aging research world with its potent SIRT1 activation and lifespan extension in simple organisms. However, its oral bioavailability of <1% in humans limits plasma levels far below concentrations needed for observed biological effects. Pterostilbene (a dimethylated resveratrol analog from blueberries) achieves 80% bioavailability while maintaining equivalent or superior SIRT1 activation.

Should I take pterostilbene instead of resveratrol?

For oral supplementation purposes, pterostilbene's dramatically superior bioavailability makes it the more rational choice. If you want the benefits that resveratrol research suggests, pterostilbene actually delivers relevant plasma concentrations.

Can pterostilbene extend human lifespan?

No direct human lifespan evidence exists. It activates SIRT1 (a validated longevity pathway) and reduces inflammatory/aging markers. Whether this translates to lifespan extension in humans cannot be confirmed with current evidence.