Quercetin's anti-inflammatory profile encompasses NLRP3 inflammasome inhibition (reducing IL-1β and IL-18 maturation), NF-κB nuclear translocation blockade (reducing inflammatory gene transcription), and direct inhibition of TNF-α, IL-6, and IL-8 production. Clinical RCTs confirm reductions in CRP and IL-6 with doses ≥500 mg/day.

How does quercetin compare to NSAIDs for inflammation?

Quercetin is less potent than NSAIDs (ibuprofen, aspirin) for acute inflammation, but offers a more favorable chronic-use safety profile (no GI ulceration, no renal risk). Quercetin's NLRP3 and NF-κB inhibition provides broader mechanism coverage than COX-2-focused NSAIDs.

Can quercetin reduce chronic joint pain?

Several small RCTs show quercetin reduces inflammatory markers in osteoarthritis and rheumatoid arthritis patients. The anti-inflammatory and senolytic (cartilage senescent cell clearance) mechanisms both contribute. Effects are modest but cumulative with regular use.