The Quercetin Phytosome® product (Indena SpA, Italy) is the most pharmacokinetically studied quercetin form. A 2011 crossover study in healthy volunteers (Di Pierro et al.) demonstrated 50x greater plasma AUC with quercetin phytosome vs equivalent doses of standard quercetin aglycone. At 200 mg phytosome quercetin, plasma concentrations exceed those achieved with 10,000 mg standard quercetin.

Is quercetin phytosome worth the premium price?

For senolytic applications where achieving senolytic plasma concentrations is essential, phytosome is almost certainly worth the premium. For general anti-inflammatory use, standard quercetin with fat is a reasonable budget alternative.

Can I use quercetin phytosome with dasatinib in the D+Q protocol?

Yes. Using phytosome form in the D+Q protocol may allow dose reduction from 1,000 mg to 200–500 mg while maintaining or exceeding the bioavailability of the original protocol. Inform your supervising physician.