Quercetin's senolytic mechanism centers on BCL-2 inhibition in senescent cells — the same strategy employed by pharmaceutical senolytic drugs. The landmark Mayo Clinic pilot study (Xu et al., 2019) demonstrated that dasatinib + quercetin (D+Q) reduced senescent cell abundance in adipose tissue biopsies, circulating SASP factors, and improved physical function in idiopathic pulmonary fibrosis patients.

Can I use quercetin as a senolytic without dasatinib?

Yes. Quercetin alone (especially in phytosome form) has documented anti-senescence and SASP-reducing effects. The D+Q combination is more potent, but quercetin-only approaches (especially combined with fisetin) represent a reasonable natural alternative.

What is the senolytic dose of quercetin?

The D+Q protocol uses quercetin 1,000 mg/day for 2 days (with dasatinib 100 mg). For natural-only protocols, quercetin phytosome 500–1,000 mg/day is used on burst days, commonly combined with fisetin 500–1,000 mg.