No human trial has directly compared senolytic cycling frequencies. Based on senescent cell reaccumulation kinetics in animals (50% recovery within 4–8 weeks) and clinical trial designs, monthly cycling is preferred for individuals 55+ or with high inflammatory burden; quarterly is appropriate for prevention in those under 50.

What happens if I miss a cycle?

Senescent cells continue to accumulate during missed cycles, but the long-term impact of occasional missed cycles is modest. Resume on your regular schedule without doubling doses.

Should I take a break from senolytic cycling?

No evidence supports "senolytic holidays." Unlike some drugs that develop resistance, senescent cells remain sensitive to senolytic treatment regardless of prior cycling history.