Senescent cell reaccumulation rate determines optimal senolytic frequency. In young-old animals (~18 months), 50% reaccumulation occurs within 6–8 weeks post-clearance. In very old animals (24+ months), reaccumulation is faster. In humans, no direct data exists, but inflammatory biomarker kinetics suggest 4–12 week optimal intervals depending on age and baseline burden.

What if I forget to cycle for a month?

Skip the missed cycle and resume on schedule. Do not double dose. The long-term pattern matters more than any single missed cycle.

Can I take senolytics more frequently than monthly?

More frequent than monthly has not been studied and is not recommended. Some beneficial roles of senescent cells (wound healing, developmental signaling) suggest chronic suppression may have unintended consequences.