High-intensity exercise, while beneficial for health, generates significant oxidative and mechanical stress that can induce senescence in muscle satellite cells and other tissues. For athletes over 35, this exercise-induced senescent cell accumulation begins to accumulate faster than the body's natural clearance capacity. Senolytics offer an evidence-supported intervention to maintain muscle regenerative capacity.

At what age should athletes start senolytics?

Athletes over 35 who notice increasing recovery time are reasonable candidates. Quarterly fisetin + daily quercetin is a appropriate starting protocol. Monthly cycling from 40+ is more aggressive but supported by the accelerated exercise-induced accumulation in older athletes.

Can senolytics improve athletic performance directly?

Not directly. Senolytics address the cellular aging that limits performance — they restore rather than enhance baseline capacity. Athletes should not expect immediate performance improvements but rather slower decline and better sustained recovery as primary benefits.