No single perfect senescent cell biomarker exists for routine clinical monitoring. The best practical approach combines inflammatory markers (hsCRP, IL-6), functional assessments (gait speed, grip strength, stair climbing), and where possible, epigenetic age testing. These together provide a reasonable picture of senolytic protocol effectiveness.

How often should I test biomarkers?

Baseline testing before starting senolytics, then re-test 4 weeks after each of the first 2–3 cycles. Once stable response is established, test every 6 months.

What labs offer p16 senescence testing?

p16 INK4A mRNA testing is available from specialized longevity labs including Life Length (telomere + senescence panel) and some academic centers. It is not available from standard commercial labs (LabCorp, Quest).