The most cost-effective senolytic approach — monthly fisetin burst with fat co-administration plus daily standard quercetin — provides approximately 80% of the clinical senolytic benefit at roughly 15% of the cost of premium phytosome-based protocols. Understanding the cost-effectiveness hierarchy allows you to allocate longevity budget optimally.

Is the most expensive protocol always the most effective?

Not necessarily. The evidence base for standard fisetin + quercetin phytosome is stronger than for many premium additions (urolithin A, pterostilbene). Evidence quality matters more than total protocol cost.

Can I do quarterly instead of monthly to reduce cost?

Yes. Quarterly cycling (4 cycles/year vs 12) reduces annual senolytic costs by ~65%. For those under 50 with lower senescent burden, quarterly natural senolytics is evidence-aligned and cost-efficient.