Senolytic drug interactions fall into two categories: (1) natural senolytic interactions (fisetin, quercetin) — generally mild and primarily relevant for anticoagulant and narrow-therapeutic-index drugs, and (2) pharmaceutical senolytic interactions (dasatinib) — clinically significant for CYP3A4 substrates and QT-prolonging drugs, requiring physician management.

I take a statin. Can I use senolytic supplements?

Yes, in most cases. Fisetin and quercetin at supplement doses are unlikely to significantly affect statin metabolism. Simvastatin and lovastatin (most CYP3A4-dependent statins) have the most theoretical interaction risk; pravastatin and rosuvastatin are not CYP3A4-metabolized and are safer to combine.

Should I stop quercetin 1 week before surgery?

Given quercetin's mild antiplatelet effects, stopping 7–10 days before elective surgery is a reasonable precaution, consistent with general guidance for supplements with antiplatelet activity.