Kidney tubular cells are particularly vulnerable to senescence due to their high metabolic activity and exposure to filtered toxins. In CKD (chronic kidney disease) and diabetic kidney disease (DKD), senescent tubular cells drive fibrosis via TGF-β-rich SASP — the same mechanism as in pulmonary fibrosis. D+Q treatment in DKD patients reduced kidney-specific senescence markers in published clinical data.

Can senolytics improve kidney function in CKD patients?

The DKD trial showed biomarker improvements consistent with reduced fibrosis and inflammation. Whether GFR measurably improves requires larger, longer trials. Current evidence supports a senolytic effect on kidney tissue but clinical functional improvement remains to be confirmed in larger studies.

Yes. Quercetin is not nephrotoxic at supplement doses. Some animal data suggests kidney protective effects via anti-oxidant and anti-inflammatory mechanisms.