Visceral adipose tissue (VAT) contains the highest concentration of senescent cells in the body — up to 20–35% of cells in VAT show senescence markers by age 65. Senescent preadipocytes and adipocytes produce an IL-6-rich, MMP-heavy SASP that impairs adipogenesis, promotes lipid dysregulation, and drives insulin resistance in hepatic and skeletal muscle tissue via inflammatory signaling.

Can senolytics reduce visceral fat?

Senolytics reduce the senescent cell fraction within visceral fat, improving its metabolic function. However, they do not reduce total fat mass — caloric restriction and exercise are necessary for that. Senolytics improve the quality of remaining fat tissue.

How quickly do metabolic markers improve after senolytics?

D+Q trials show metabolic marker improvements within 4–8 weeks of treatment. Fasting glucose and adiponectin respond faster than structural improvements in body composition.