Natural senolytic side effects are predominantly mild and transient, occurring in approximately 15–30% of first-cycle users. The most common — mild fatigue, headache, and GI discomfort within 24 hours of dosing — likely represent the normal inflammatory response to dying senescent cells releasing their SASP contents. These typically resolve within 24–48 hours without intervention.

Is it normal to feel worse before feeling better with senolytics?

Yes, for some users. The transient inflammatory signal from dying senescent cells (SASP release) can cause temporary symptom worsening. This typically resolves within 48 hours and subsequent cycles are usually better tolerated as senescent cell burden decreases.

How long should I wait after an injury before taking senolytics?

Wait until wound healing is substantially complete (approximately 2–4 weeks post-injury). The senescent cells involved in wound repair (which produce PDGF-AA and promote healing) should be allowed to complete their function before clearance.