Sleep is the primary glymphatic clearance window — during deep sleep, the glymphatic system clears tau proteins, amyloid-beta, and SASP factors from brain tissue. Chronic sleep deprivation (< 7 hours) is associated with 20–30% higher circulating inflammatory markers and measurably higher senescent cell burden. Optimizing sleep quality creates a more favorable environment for senolytic protocols.

Does fisetin improve sleep quality directly?

No direct sleep-promoting mechanism. However, reduced systemic inflammation from senolytic activity may improve sleep quality indirectly — chronic inflammation disrupts sleep architecture.

Should I time senolytic burst days around sleep cycles?

Ensuring excellent sleep on senolytic burst days and the nights immediately after may support effective cellular clearance. Avoid senolytic burst days during periods of significant sleep disruption.