Estrogen maintains low senescent cell burden via multiple mechanisms: promoting BCL-2-independent apoptosis of damaged cells, supporting DNA repair via BRCA1/2 upregulation, and reducing oxidative stress via Nrf2 activation. Menopause removes all three mechanisms simultaneously, creating the fastest acceleration of senescent cell accumulation in any human life stage.

Should I use senolytics instead of hormone replacement therapy?

No. HRT restores estrogen signaling throughout the body. Senolytics address one downstream consequence of estrogen loss (senescent cell accumulation). They are complementary, not interchangeable. Many physicians now discuss both options together for post-menopausal health optimization.

Are natural senolytics safe during perimenopause?

Yes. Fisetin and quercetin are natural compounds with extensive safety data. They do not affect estrogen levels and have no clinically significant hormonal activity.