Beginning a senolytic protocol safely requires: (1) establishing baseline inflammatory biomarkers, (2) choosing the appropriate starting agent (fisetin for most), (3) optimizing fat co-administration for absorption, (4) scheduling the first burst on a rest day, and (5) monitoring for common first-cycle experiences. This structured approach maximizes benefit while managing the mild discomfort some users experience in early cycles.

What if I feel worse after my first senolytic cycle?

Mild first-cycle symptoms (fatigue, GI discomfort, headache) are common and usually resolve within 24–48 hours. This likely reflects SASP release from dying senescent cells. Hydrate well, rest, and the symptoms typically clear. If symptoms persist beyond 72 hours or are severe, stop and consult a physician.

Should I take senolytics if I have a cold or flu?

No. Acute infections involve beneficial inflammatory responses and some protective senescence mechanisms. Postpone senolytic burst days until fully recovered.