Urolithin A (UA) is a gut-microbiome-derived metabolite from ellagitannins in pomegranates, walnuts, and berries. It activates mitophagy (selective autophagy of dysfunctional mitochondria) via AMPK and PINK1/Parkin pathway activation. Human clinical trials show UA supplementation improves mitochondrial function markers and muscle endurance in older adults — making it one of the most evidence-backed mitochondrial longevity supplements available.

No. Urolithin A activates mitophagy within cells, clearing damaged mitochondria. It does not directly induce apoptosis in senescent cells. It is a mitochondrial quality control agent, not a senolytic — but the two are complementary aging interventions.

Can I get urolithin A from pomegranate juice?

Only if your gut microbiome produces urolithin A from pomegranate ellagitannins. Given the ~30–40% producer rate in the population, pomegranate juice is unreliable. Supplemental urolithin A bypasses this limitation.