Pomegranate, walnuts and berries around a mitochondrion

Urolithin A Dose Calculator

Choose mitochondrial health or muscle endurance to compare amounts tested in human trials. This is not a weight-based dose or a proven longevity treatment.

How to read your result

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Your dose

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Evidence range / upper limit

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Review the safety notes

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Evidence grade C

Medication & safety cautions

How this estimate works

Mitochondrial-health context: 500 mg once daily. Muscle-endurance context: 1,000 mg once daily, at any time. Human trials have used 250–1,000 mg/day; these studies do not establish a lifespan benefit. The suggested review window is 8–16 weeks.

Key studies

  1. Andreux et al. 2019 — Nature Metabolism · first-in-human urolithin A study
  2. Liu et al. 2022 — JAMA Network Open · trial in older adults
  3. Singh et al. 2022 — Cell Reports Medicine · randomized trial in middle-aged adults

Urolithin A clinical trials review · Intervention evidence

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Timeline Mitopure Urolithin A Softgels

Best for: the softgel option discussed in the clinical-trials guide

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Timeline Mitopure Urolithin A Powder

Best for: the powder option discussed in the clinical-trials guide

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Frequently asked questions

Is urolithin A dose based on body weight?

No. The 500 mg and 1,000 mg amounts shown are fixed amounts used in human trials.

Does the calculator predict a longevity benefit?

No. Human trials have studied biomarkers and physical-function outcomes; a longer lifespan benefit has not been demonstrated.

Can I use urolithin A while pregnant or breastfeeding?

Pregnancy and breastfeeding safety data are limited; this calculator does not provide a dose.

Educational tool, not medical advice. Check with your doctor, especially if you take medication.