Tocotrienols (particularly delta- and gamma-tocotrienol from annatto) have distinct biological activities from alpha-tocopherol: they inhibit HMG-CoA reductase (independent statin-like effect), potently inhibit NF-κB at lower concentrations than tocopherols, and demonstrate selective pro-apoptotic activity in senescent and pre-malignant cells not shared by standard vitamin E.

Are annatto tocotrienol supplements effective?

Annatto tocotrienol supplements (standardized to delta- and gamma-tocotrienol content) have human cardiovascular evidence. For senolytic applications, human evidence is limited but mechanistic data is promising.

How should I take tocotrienol supplements?

Take with a fat-containing meal (tocotrienols are fat-soluble) and at a different time from alpha-tocopherol supplements or multivitamins containing vitamin E.