Captopril (ACE inhibitor)

Estimated longevity benefit: +1.0 years. Evidence score: 68/100.

Captopril is an ACE inhibitor that relaxes blood vessels by blocking the renin-angiotensin system, thereby reducing cardiovascular workload and systemic inflammation. Its unique ability to extend both median and maximum lifespan in animal models suggests that vascular preservation is a primary target for slowing systemic aging.