Estimated longevity benefit: +0.8 years. Evidence score: 100/100.
Tadalafil is a PDE5 inhibitor that improves endothelial function by preventing cGMP breakdown and sustaining nitric oxide signaling throughout the entire vascular system. Daily 5 mg dosing maintains stable plasma levels around the clock, providing continuous cardiovascular protection, reduced arterial stiffness, improved cerebral perfusion, and measurable reductions in all-cause mortality in large population studies.