Genetic testing reveals risk factors and traits, but lifestyle choices still dominate longevity outcomes for most people.
How much does genetics determine your lifespan? Research suggests genes account for only 25-30% of lifespan variation. The rest is lifestyle and environment.
If you have APOE4, aggressive cardiovascular prevention is warranted.
MTHFR variants may benefit from methylated B vitamins.
Many variants slightly increase or decrease risk without clear interventions.
David Sinclair argues that while genetics loads the gun, epigenetics pulls the trigger. Lifestyle choices influence gene expression regardless of genetic variants.